TIMP2 Antikörper (N-Term)

Produktnummer ABIN2787967

Dieses Anti-TIMP2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TIMP2 in WB und IHC. Geeignet für Human, Ratte, Maus, Rind (Kuh), Zebrafisch (Danio rerio), Kaninchen, Meerschweinchen, Hund, Pferd und Schaf.

Kurzübersicht für TIMP2 Antikörper (N-Term) (ABIN2787967)

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Zebrafisch (Danio rerio), Kaninchen, Meerschweinchen, Hund, Pferd, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-TIMP2 Antikörper

Bindungsspezifität: N-Term

Sequenz: NADVVIRAKA VSEKEVDSGN DIYGNPIKRI QYEIKQIKMF KGPEKDIEFI

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 93%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against TIMP2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TIMP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 220 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Andere Bezeichnung: TIMP2

Hintergrund: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Alias Symbols: CSC-21K, Metalloproteinase inhibitor 2, TIMP2, TIMP metallopeptidase inhibitor 2, Tissue inhibitor of metalloproteinases 2, Timp2
Protein Interaction Partner: BAG3, ITGA3, MMP14, ITGB1, MMP2, MMP8, SNCG, PSMA7,
Protein Size: 220

Molekulargewicht: 22 kDa

Gen-ID: 7077

NCBI Accession: NM_003255, NP_003246

UniProt: P16035

Pathways: cAMP Metabolic Process