GARS Antikörper (Middle Region)

Produktnummer ABIN2787816

Produktdetails anti-GARS Antikörper

Target: GARS (Glycyl-tRNA Synthetase (GARS))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GARS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: IEPSFGLGRI MYTVFEHTFH VREGDEQRTF FSFPAVVAPF KCSVLPLSQN

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against GARS. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GARS

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 739 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GARS

Target: GARS (Glycyl-tRNA Synthetase (GARS))

Andere Bezeichnung: GARS (GARS Produkte)

Hintergrund: GARS catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CMT2D, DSMAV, GlyRS, HMN5, SMAD1
Protein Interaction Partner: UBC, STAU1, NEDD8, DCP2, TNRC6B, CAND1, GORASP2, CORO1C, BOP1, GANAB, XPO7, HSPA4L, VAT1, SEC23A, TOM1, KHSRP, HIRIP3, HIST1H4A, USP11, ZYX, UGDH, TTC1, TROVE2, SNX1, SHMT1, PPM1G, OSBP, NCBP1, ME1, GTF2A1, GFPT1, CTTN, CTNNA1, CARS, APEH, MAPK8, MAP3K10,
Protein Size: 739

Molekulargewicht: 83 kDa

Gen-ID: 2617

NCBI Accession: NM_002047, NP_002038

UniProt: P41250

Pathways: Ribonucleoside Biosynthetic Process