MVP Antikörper (N-Term)

Produktnummer ABIN2787778

Dieses Anti-MVP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MVP in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Kaninchen, Zebrafisch (Danio rerio), Hund, Pferd, Meerschweinchen und Schwein.

Kurzübersicht für MVP Antikörper (N-Term) (ABIN2787778)

Target: MVP (Major Vault Protein (MVP))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Zebrafisch (Danio rerio), Hund, Pferd, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MVP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MVP Antikörper

Bindungsspezifität: N-Term

Sequenz: MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against MVP. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MVP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 893 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MVP

Target: MVP (Major Vault Protein (MVP))

Andere Bezeichnung: MVP

Hintergrund: MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences, however, the open reading frames are the same in both transcripts.
Alias Symbols: LRP, VAULT1
Protein Interaction Partner: MVP, SKIL, TRIM27, REL, PLSCR1, MEOX2, MEOX1, MDFI, KPNA3, GOLGA2, DLX2, CAMK2B, AES, TRIP6, TRAF2, TP53, TFCP2, TCF4, SUMO2, NOTCH2NL, CCDC36, TRIM42, FAM154A, PIH1D2, RAB3IP, RIMBP3, C1orf94, RHOXF2, ZMIZ2, OBFC1, RFWD2, MKL1, VAC14, BANP, FAM46C, KCTD9
Protein Size: 893

Molekulargewicht: 98 kDa

Gen-ID: 9961

NCBI Accession: NM_005115, NP_005106

UniProt: Q14764