PPP4C Antikörper (Middle Region)
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- Target Alle PPP4C Antikörper anzeigen
- PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd, Meerschweinchen, Zebrafisch (Danio rerio), Saccharomyces cerevisiae
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PPP4C Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- TVLTVWSAPN YCYRCGNVAA ILELDEHLQK DFIIFEAAPQ ETRGIPSKKP
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against PPP4C. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PPP4C
- Top Product
- Discover our top product PPP4C Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 307 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))
- Andere Bezeichnung
- PPP4C (PPP4C Produkte)
- Synonyme
- pp4 antikoerper, ppx antikoerper, pp4c antikoerper, pph3 antikoerper, MGC75928 antikoerper, PP4C-A antikoerper, gc:56413 antikoerper, ppp4c antikoerper, wu:fd05e08 antikoerper, zgc:56413 antikoerper, PP4 antikoerper, PP4C antikoerper, PPH3 antikoerper, PPP4 antikoerper, PPX antikoerper, 1110002D08Rik antikoerper, AU016079 antikoerper, Ppx antikoerper, protein phosphatase 4 catalytic subunit antikoerper, protein phosphatase 4, catalytic subunit a antikoerper, protein phosphatase 4, catalytic subunit antikoerper, protein phosphatase 4 catalytic subunit S homeolog antikoerper, ppp4c antikoerper, ppp4ca antikoerper, PPP4C antikoerper, Ppp4c antikoerper, ppp4c.S antikoerper
- Hintergrund
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PPP4C is a protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase.
Alias Symbols: PP4, PPH3, PPX, PP4C, PPP4
Protein Interaction Partner: SUMO2, IKBKG, MAP4K1, BAG6, TCP1, UBC, CAND1, CUL3, Igbp1, TRIM28, ELAVL1, TK1, PPP2R5D, PPP2R4, PPP2R2B, PPP2R1A, EEF1A1, CCT6A, SMEK2, PPP2R2D, SMEK1, ATAD3A, PPME1, CCT5, CCT8, CCT2, CCT4, CCT7, PPP4R1, PLOD3, CCDC6, TUBA3C, CCT3, CCT6P1, GLYATL3, PPP4
Protein Size: 307 - Molekulargewicht
- 34 kDa
- Gen-ID
- 5531
- NCBI Accession
- NM_002720, NP_002711
- UniProt
- P60510
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