PNPO Antikörper (N-Term)

Produktnummer ABIN2787718

Dieses Anti-PNPO-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PNPO in WB. Geeignet für Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen und Kaninchen. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für PNPO Antikörper (N-Term) (ABIN2787718)

Target: PNPO (Pyridoxamine 5'-Phosphate Oxidase (PNPO))

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PNPO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PNPO Antikörper

Bindungsspezifität: N-Term

Sequenz: PMRKSYRGDR EAFEETHLTS LDPVKQFAAW FEEAVQCPDI GEANAMCLAT

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PNPO. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PNPO

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 261 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PNPO Antikörper (ABIN2787718)

Song, Ueno, Numata, Iga, Shibuya-Tayoshi, Nakataki, Tayoshi, Yamauchi, Sumitani, Tomotake, Tada, Tanahashi, Itakura, Ohmori: "Association between PNPO and schizophrenia in the Japanese population." in: Schizophrenia research, Vol. 97, Issue 1-3, pp. 264-70, (2007) (PubMed).

Details zu PNPO

Target: PNPO (Pyridoxamine 5'-Phosphate Oxidase (PNPO))

Andere Bezeichnung: PNPO

Hintergrund: PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.Vitamin B6, or pyridoxal 5-prime-phosphate (PLP), is critical for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. The rate-limiting enzyme in vitamin B6 synthesis is pyridoxine-5-prime-phosphate (PNP) oxidase (PNPO, EC 1.4.3.5).[supplied by OMIM].
Alias Symbols: FLJ10535, PDXPO
Protein Interaction Partner: UBC, LPP, APP, ELAVL1,
Protein Size: 261

Molekulargewicht: 29 kDa

Gen-ID: 55163

NCBI Accession: NM_018129, NP_060599

UniProt: Q9NVS9