ACTN1 Antikörper (N-Term)

Produktnummer ABIN2787669

Dieses Anti-ACTN1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ACTN1 in WB und IHC. Geeignet für Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Zebrafisch (Danio rerio) und Pferd.

Kurzübersicht für ACTN1 Antikörper (N-Term) (ABIN2787669)

Target: ACTN1 (Actinin, alpha 1 (ACTN1))

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Zebrafisch (Danio rerio), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACTN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ACTN1 Antikörper

Bindungsspezifität: N-Term

Sequenz: DHYDSQQTND YMQPEEDWDR DLLLDPAWEK QQRKTFTAWC NSHLRKAGTQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 75%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against ACTN1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ACTN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 892 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ACTN1

Target: ACTN1 (Actinin, alpha 1 (ACTN1))

Andere Bezeichnung: ACTN1

Hintergrund: Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ40884
Protein Interaction Partner: SPERT, KCTD6, MICALL2, MYOZ2, EPM2AIP1, OAS1, ACTN3, ACTN1, SUMO2, SUMO3, HSF5, UBC, MDM2, EZH2, BMI1, ACTN4, CDAN1, DCAF8, SF3A3, STAM2, SRP19, UBD, IGSF8, ICAM1, CD81, ERBB2IP, SVIL, PDHX, RPS27, PSMA1, KPNA2, HCVgp1, PIAS4, GIT2, NUMBL, HSP90AB1, HSP90
Protein Size: 892

Molekulargewicht: 103 kDa

Gen-ID: 87

NCBI Accession: NM_001102, NP_001093

UniProt: P12814

Pathways: Cell-Cell Junction Organization