MED14 Antikörper (Middle Region)

Produktnummer ABIN2787568

Produktdetails anti-MED14 Antikörper

Target: MED14 (Mediator Complex Subunit 14 (MED14))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MED14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Sequenz: AADREDSPAM ALLLQQFKEN IQDLVFRTKT GKQTRTNAKR KLSDDPCPVE

Homologie: Human: 100%, Mouse: 79%, Rabbit: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against MED14. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MED14

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1454 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MED14

Target: MED14 (Mediator Complex Subunit 14 (MED14))

Andere Bezeichnung: MED14 (MED14 Produkte)

Synonyme: CG12031 antikoerper, Dmel\\CG12031 antikoerper, Med14 antikoerper, Trap170 antikoerper, dTRAP170 antikoerper, p160 antikoerper, EXLM1 antikoerper, crsp150 antikoerper, crsp2 antikoerper, trap170 antikoerper, wu:fd21c05 antikoerper, wu:fk28h11 antikoerper, CRSP2 antikoerper, NV18605 antikoerper, CRSP150 antikoerper, CSRP antikoerper, CXorf4 antikoerper, DRIP150 antikoerper, RGR1 antikoerper, TRAP170 antikoerper, 9930001L01Rik antikoerper, AU041628 antikoerper, Crsp2 antikoerper, ENSMUSG00000073278 antikoerper, Gm641 antikoerper, ORF1 antikoerper, RGD1560170 antikoerper, Mediator complex subunit 14 antikoerper, mediator complex subunit 14 antikoerper, mediator of RNA polymerase II transcription subunit 14 antikoerper, transcriptional regulation antikoerper, MED14 antikoerper, med14 antikoerper, LOC100113592 antikoerper, Med14 antikoerper, RGR1 antikoerper

Hintergrund: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
Alias Symbols: CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, MGC104513, RGR1, TRAP170
Protein Interaction Partner: UBC, HECW2, CDK8, CDK19, MED12, ESR1, MED19, MED26, PPARG, FBXW7, EPAS1, MED11, MED8, MED29, MED18, MED4, PPP6R1, MED16, MED13, MED24, MED27, MED17, MED21, MED1, CTDP1, SREBF1, DCTN1, ACTN2, ACTN1, MED10, UACA, NECAB2, MED25, MED15, CRSP5, MED7, MED23, VD
Protein Size: 1454

Molekulargewicht: 160 kDa

Gen-ID: 9282

NCBI Accession: NM_004229, NP_004220

UniProt: O60244

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha