ATF5 Antikörper (Middle Region)

Produktnummer ABIN2787491

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ATF5 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio) und Hund.Es wurde in 1 Publikation zitiert.

Kurzübersicht für ATF5 Antikörper (Middle Region) (ABIN2787491)

Target: ATF5 (Activating Transcription Factor 5 (ATF5))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATF5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ATF5 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: ATF5 Antibody - middle region

Sequenz: LPPPQQPPPP SPPQPSRLAP YPHPATTRGD RKQKKRDQNK SAALRYRQRK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against ATF5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATF5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57977-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ATF5 Antikörper (ABIN2787491)

Wei, Jiang, Liu, Zhou, Chen, Zhang, Zong, Yun, Gu: "Cdc34-mediated degradation of ATF5 is blocked by cisplatin." in: The Journal of biological chemistry, Vol. 283, Issue 27, pp. 18773-81, (2008) (PubMed).

Details zu ATF5

Target: ATF5 (Activating Transcription Factor 5 (ATF5))

Andere Bezeichnung: ATF5

Hintergrund:

Background Information: ATF5 belongs to the bZIP family. It is transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Loss of ATF5 is associated with hepatocellular carcinoma.

Gene Name: Activating transcription factor 5

Alternative Symbols: ATFX, HMFN0395

Protein Name: Cyclic AMP-dependent transcription factor ATF-5

Molekulargewicht: 31kDa

Gen-ID: 22809

NCBI Accession: NP_036200

UniProt: B3KND3

Pathways: Myometrial Relaxation and Contraction