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Glutaredoxin 2 Antikörper (Middle Region)

This anti-Glutaredoxin 2 antibody (ABIN2787395) is a Rabbit Polyclonal antibody detecting Glutaredoxin 2 in WB. Suitable for Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep.
Produktnummer ABIN2787395

Quick Overview for Glutaredoxin 2 Antikörper (Middle Region) (ABIN2787395)

Target

Alle Glutaredoxin 2 (GRX2) Antikörper anzeigen
Glutaredoxin 2 (GRX2)

Reaktivität

Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Schaf

Wirt

  • 42
  • 6
Kaninchen

Klonalität

  • 46
  • 2
Polyklonal

Konjugat

  • 22
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Glutaredoxin 2 Antikörper ist unkonjugiert

Applikation

  • 34
  • 22
  • 13
  • 13
  • 12
  • 10
  • 8
  • 7
  • 6
  • 3
  • 3
  • 2
Western Blotting (WB)
  • Bindungsspezifität

    • 16
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequenz

    NVNYKVVELD LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL H

    Homologie

    Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 86%, Sheep: 86%

    Produktmerkmale

    This is a rabbit polyclonal antibody against GLRX2. It was validated on Western Blot.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the middle region of human GLRX2
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 164 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    Glutaredoxin 2 (GRX2)

    Andere Bezeichnung

    GLRX2

    Hintergrund

    GLRX2 is a glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress.GLRX2 is involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.GLRX2 acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides.GLRX2 can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.GLRX2 efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression of GLRX2 decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
    Alias Symbols: GRX2, bA101E13.1, CGI-133
    Protein Interaction Partner: BAG3, TXNRD1,
    Protein Size: 164

    Molekulargewicht

    18 kDa

    Gen-ID

    51022

    NCBI Accession

    NM_197962, NP_932066

    UniProt

    Q9NS18

    Pathways

    Cell RedoxHomeostasis
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