ASAH1 Antikörper (N-Term)

Produktnummer ABIN2787375

Es sind 2+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-ASAH1 Antikörper wird verwendet zum Nachweis von ASAH1 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für ASAH1 Antikörper (N-Term) (ABIN2787375)

Target: ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASAH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ASAH1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: ASAH1 Antibody - N-terminal region

Sequenz: MPGRSCVALV LLAAAVSCAV AQHAPPWTED CRKSTYPPSG PTYRGAVPWY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ASAH1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ASAH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57760-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ASAH1 Antikörper (ABIN2787375)

Tan, Liu, Fox, Barth, Sharma, Turner, Awwad, Dewey, Doi, Spitzer, Shah, Morad, Desai, Amin, Zhu, Liao, Yun, Kester, Claxton, Wang, Cabot, Schuchman, Levine, Feith, Loughran: "Acid ceramidase is upregulated in AML and represents a novel therapeutic target." in: Oncotarget, Vol. 7, Issue 50, pp. 83208-83222, (2016) (PubMed).

Elamin, Titz, Dijon, Merg, Geertz, Schneider, Martin, Schlage, Frentzel, Talamo, Phillips, Veljkovic, Ivanov, Vanscheeuwijck, Peitsch, Hoeng: "Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice." in: Journal of proteomics, Vol. 145, pp. 237-45, (2016) (PubMed).

Details zu ASAH1

Target: ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))

Andere Bezeichnung: ASAH1

Hintergrund:

Background Information: This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into

Gene Name: N-acylsphingosine amidohydrolase (acid ceramidase) 1

Alternative Symbols: AC, PHP, ASAH, PHP32, ACDase, SMAPME

Protein Name: Acid ceramidase

Molekulargewicht: 45 kDa

Gen-ID: 427

NCBI Accession: NP_808592

UniProt: Q13510