CALCOCO1 Antikörper (N-Term)

Produktnummer ABIN2787240

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch CALCOCO1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen und Rind (Kuh).

Kurzübersicht für CALCOCO1 Antikörper (N-Term) (ABIN2787240)

Target: CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CALCOCO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CALCOCO1 Antikörper

Bindungsspezifität: N-Term

Sequenz: ESTTDGSPIH TSVQFQASYL PKPGAQLYQF RYVNRQGQVC GQSPPFQFRE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CALCOCO1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CALCOCO1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 691 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CALCOCO1

Target: CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))

Andere Bezeichnung: CALCOCO1

Hintergrund: CALCOCO1 functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR).CALCOCO1 is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. CALCOCO1 is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. CALCOCO1 functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.
Alias Symbols: Cocoa, KIAA1536, PP13275, calphoglin
Protein Interaction Partner: CWF19L2, CEP19, FAM161A, TBC1D15, DUSP13, ISOC1, GABARAPL2, NDC80, UBC, GRIK2, APP, APTX, EP300, CTNNB1, NEDD4, HIST1H4A, HIST1H3A, PCBD1, TBC1D17, CTNNBL1, CYTH3, SH3GL3, CRYBA2, CREBBP, MAPK1, KRT15, IPP, FOSL1,
Protein Size: 691

Molekulargewicht: 77 kDa

Gen-ID: 57658

NCBI Accession: NM_020898, NP_065949

UniProt: Q9P1Z2

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Chromatin Binding