C11orf73 Antikörper (Middle Region)

Produktnummer ABIN2786966

Der Kaninchen Polyklonal anti-C11orf73 Antikörper (ABIN2786966) detektiert spezifisch C11orf73 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Pferd, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio), Schwein und Saccharomyces cerevisiae.

Kurzübersicht für C11orf73 Antikörper (Middle Region) (ABIN2786966)

Target: C11orf73 (Chromosome 11 Open Reading Frame 73 (C11orf73))

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio), Schwein, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C11orf73 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-C11orf73 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: HIKESHI Antibody - middle region

Sequenz: DNFYNFASSF AVSQAQMTPS PSEMFIPANV VLKWYENFQR RLAQNPLFWK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 90%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 90%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against C11orf73. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human C11orf73

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56903-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu C11orf73

Target: C11orf73 (Chromosome 11 Open Reading Frame 73 (C11orf73))

Andere Bezeichnung: HIKESHI

Hintergrund:

Background Information: This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress.

Gene Name: Hikeshi, heat shock protein nuclear import factor

Alternative Symbols: HLD13, L7RN6, OPI10, HSPC138, HSPC179, C11orf73

Protein Name: protein Hikeshi

Molekulargewicht: 21kDa

Gen-ID: 51501

NCBI Accession: NP_057485

UniProt: Q53FT3

Pathways: Protein targeting to Nucleus