PKC eta Antikörper (N-Term)

Produktnummer ABIN2786852

Produktdetails anti-PKC eta Antikörper

Target: PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Pferd, Zebrafisch (Danio rerio), Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKC eta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KKGHQLLDPY LTVSVDQVRV GQTSTKQKTN KPTYNEEFCA NVTDGGHLEL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against PRKCH. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRKCH

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 683 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PKC eta

Target: PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))

Andere Bezeichnung: PRKCH (PRKCH Produkte)

Synonyme: PKC-L antikoerper, PKCL antikoerper, PRKCL antikoerper, nPKC-eta antikoerper, Pkch antikoerper, pkc-eta antikoerper, PRKCH antikoerper, prkch antikoerper, si:ch211-212g7.5 antikoerper, zgc:172124 antikoerper, protein kinase C eta antikoerper, protein kinase C, eta antikoerper, protein kinase C eta L homeolog antikoerper, protein kinase C, eta, b antikoerper, protein kinase C, eta, a antikoerper, protein kinase C epsilon antikoerper, PRKCH antikoerper, Prkch antikoerper, prkch.L antikoerper, prkchb antikoerper, prkcha antikoerper, prkch antikoerper, PRKCE antikoerper

Hintergrund: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.
Alias Symbols: MGC26269, MGC5363, PKC-L, PKCL, PRKCL, nPKC-eta
Protein Interaction Partner: BANP, HSP90AA1, GSK3A, PPP1R14A, UBC, VHL, PRKCH, NFE2L2, MGMT, ZBTB8OS, PARD6A, PRKD1, NUMB, ITGB2, SRC, PTPN11, FYN, CDK2, PDPK1, AKAP13,
Protein Size: 683

Molekulargewicht: 78 kDa

Gen-ID: 5583

NCBI Accession: NM_006255, NP_006246

UniProt: P24723

Pathways: Myometrial Relaxation and Contraction, Thromboxane A2 Receptor Signaling