GOPC Antikörper (N-Term)

Produktnummer ABIN2786578

Produktdetails anti-GOPC Antikörper

Target: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GOPC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EVLEKEFDKA FVDVDLLLGE IDPDQADITY EGRQKMTSLS SCFAQLCHKA

Homologie: Cow: 100%, Dog: 86%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against GOPC. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GOPC

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 454 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GOPC

Target: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Andere Bezeichnung: GOPC (GOPC Produkte)

Hintergrund: GOPC plays a role in intracellular protein trafficking and degradation. GOPC may regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. GOPC may also regulate the intracellular trafficking of the ADR1B receptor. GOPC may play a role in autophagy. Overexpression of GOPC results in CFTR intracellular retention and degradation in the lysosomes.PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM].
Alias Symbols: CAL, FIG, GOPC1, PIST, dJ94G16.2
Protein Interaction Partner: BATF, SSNA1, VTN, MYLK, HCK, FOSL2, DPYD, RPL13AP17, C17orf67, ZSCAN1, LCLAT1, FAM9B, ZBTB49, ZNF564, SPATA8, RNF183, MORN4, MYOCD, MUM1, ZNF587, SLC25A18, CCDC102B, AKIRIN1, MRPL1, SEMA4G, RNF220, FAM90A1, PID1, ZNF581, CERCAM, RHOQ, PARK7, STARD3, HSF1,
Protein Size: 454

Molekulargewicht: 50 kDa

Gen-ID: 57120

NCBI Accession: NM_001017408, NP_001017408

UniProt: Q9HD26

Pathways: Maintenance of Protein Location, Asymmetric Protein Localization