AKTIP Antikörper (Middle Region)

Produktnummer ABIN2786570

Dieses Anti-AKTIP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von AKTIP in WB. Geeignet für Human, Maus, Ratte, Hund, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh), Meerschweinchen und Pferd. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für AKTIP Antikörper (Middle Region) (ABIN2786570)

Target: AKTIP (AKT Interacting Protein (AKTIP))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh), Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKTIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-AKTIP Antikörper

Bindungsspezifität: Middle Region

Sequenz: NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against AKTIP. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AKTIP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 292 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-AKTIP Antikörper (ABIN2786570)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Details zu AKTIP

Target: AKTIP (AKT Interacting Protein (AKTIP))

Andere Bezeichnung: AKTIP

Hintergrund: AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Alias Symbols: FT1, FTS
Protein Interaction Partner: HOOK1, HOOK2, HOOK3, FAM160A2, VPS16, VPS18, VPS41, TRIM23, TRIM41, MARCH5, DZIP3, KIAA1377, EXOC7, POLA2, GTF3C1, UTP14A, C10orf2, PDPK1, ASS1, CTBP2, IMMT, RPA1, AKT1, TIMM50, PDS5A, IARS, HDLBP, DCTN1,
Protein Size: 292

Molekulargewicht: 33 kDa

Gen-ID: 64400

NCBI Accession: NM_001012398, NP_001012398

UniProt: Q9H8T0