BLMH Antikörper (Middle Region)

Produktnummer ABIN2786515

Der Kaninchen Polyklonal anti-BLMH Antikörper (ABIN2786515) detektiert spezifisch BLMH in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Hund, Meerschweinchen, Zebrafisch (Danio rerio), Rind (Kuh), Pferd und Kaninchen.

Kurzübersicht für BLMH Antikörper (Middle Region) (ABIN2786515)

Target: BLMH (Bleomycin Hydrolase (BLMH))

Reaktivität: Human, Ratte, Maus, Hund, Meerschweinchen, Zebrafisch (Danio rerio), Rind (Kuh), Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BLMH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BLMH Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: BLMH Antibody - middle region

Sequenz: EYLSNMVGGR KTLYNNQPID FLKKMVAASI KDGEAVWFGC DVGKHFNSKL

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against BLMH. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BLMH

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56106-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu BLMH

Target: BLMH (Bleomycin Hydrolase (BLMH))

Andere Bezeichnung: BLMH

Hintergrund:

Background Information: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution, however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Bleomycin hydrolase

Alternative Symbols: BH, BMH

Protein Name: Bleomycin hydrolase

Molekulargewicht: 52kDa

Gen-ID: 642

NCBI Accession: NP_000377

UniProt: Q13867