BLMH Antikörper (Middle Region)

Produktnummer ABIN2786515

Dieses Anti-BLMH-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BLMH in WB. Geeignet für Human, Ratte, Maus, Hund, Meerschweinchen, Zebrafisch (Danio rerio), Rind (Kuh), Pferd und Kaninchen.

Kurzübersicht für BLMH Antikörper (Middle Region) (ABIN2786515)

Target: BLMH (Bleomycin Hydrolase (BLMH))

Reaktivität: Human, Ratte, Maus, Hund, Meerschweinchen, Zebrafisch (Danio rerio), Rind (Kuh), Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BLMH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BLMH Antikörper

Bindungsspezifität: Middle Region

Sequenz: EYLSNMVGGR KTLYNNQPID FLKKMVAASI KDGEAVWFGC DVGKHFNSKL

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against BLMH. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BLMH

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 455 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BLMH

Target: BLMH (Bleomycin Hydrolase (BLMH))

Andere Bezeichnung: BLMH

Hintergrund: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution, however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BH, BMH
Protein Interaction Partner: NUDT12, WDYHV1, BLMH, UBC, ZBTB1, SH3GLB2, LZTFL1, GORASP2, PES1, GTF2A1, AP1M2, CYP2C8, RNF32, ECSIT, MAST1, COPS5, CUL4B, SUMO2, PDPK1, Fam134a, USP53, KBTBD7, RPL11, UBE2I, TRIO, RPL29, APP,
Protein Size: 455

Molekulargewicht: 52 kDa

Gen-ID: 642

NCBI Accession: NM_000386, NP_000377

UniProt: Q13867