HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd) (N-Term) Antikörper

Produktnummer ABIN2786479

Produktdetails

Target: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TGSPYSTNCW LCTSSSTETP GTAYPASPRE WTSIEAELHI SYRWDPNLKG

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HERV-FRD. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HERV-FRD

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 538 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen

Malassiné, Frendo, Blaise, Handschuh, Gerbaud, Tsatsaris, Heidmann, Evain-Brion: "Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta." in: Retrovirology, Vol. 5, pp. 6, (2008) (PubMed).

Antigendetails

Target: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Andere Bezeichnung: HERV-FRD (Herv-frd Produkte)

Synonyme: ERVFRDE1 antikoerper, GLLL6191 antikoerper, HERV-FRD antikoerper, HERV-W/FRD antikoerper, UNQ6191 antikoerper, envFRD antikoerper, Gm52 antikoerper, Syna antikoerper, endogenous retrovirus group FRD member 1, envelope antikoerper, ERVFRD-1 antikoerper, Ervfrd-1 antikoerper

Substanzklasse: Viral Protein

Hintergrund: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8 % of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1, MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].
Alias Symbols: FLJ41944, FLJ90611, GLLL6191, MGC87585, UNQ6191, envFRD, ERVFRDE1, HERV-FRD, HERV-W/FRD
Protein Interaction Partner: APP,
Protein Size: 538

Molekulargewicht: 60 kDa

Gen-ID: 405754

NCBI Accession: NM_207582, NP_997465

UniProt: P60508