NSMCE2 Antikörper (Middle Region)

Produktnummer ABIN2786320

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NSMCE2 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Kaninchen, Pferd, Meerschweinchen und Rind (Kuh).

Kurzübersicht für NSMCE2 Antikörper (Middle Region) (ABIN2786320)

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Reaktivität: Human, Maus, Kaninchen, Pferd, Meerschweinchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSMCE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NSMCE2 Antikörper

Bindungsspezifität: Middle Region

Sequenz: KFLALQSKNS DADFQNNEKF VQFKQQLKEL KKQCGLQADR EADGTEGVDE

Homologie: Cow: 86%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NSMCE2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NSMCE2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 247 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NSMCE2

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Andere Bezeichnung: NSMCE2

Hintergrund: NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
Alias Symbols: C8orf36, FLJ32440, MMS21, NSE2
Protein Interaction Partner: TXLNA, PAN2, UBC, NSMCE1, SMC6, PDS5A, SMC5, WAPAL, PDS5B, STAG2, SMC3, SMC1A, SUMO1, TSNAX, RAD21, ETV1, SUMO2,
Protein Size: 247

Molekulargewicht: 28 kDa

Gen-ID: 286053

NCBI Accession: NM_173685, NP_775956

UniProt: Q96MF7