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SPAG8 Antikörper (Middle Region)

SPAG8 Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Schwein WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2786290
  • Target Alle SPAG8 Antikörper anzeigen
    SPAG8 (Sperm Associated Antigen 8 (SPAG8))
    Bindungsspezifität
    • 15
    • 8
    • 8
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Schwein
    Wirt
    • 44
    • 4
    Kaninchen
    Klonalität
    • 46
    • 2
    Polyklonal
    Konjugat
    • 20
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SPAG8 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 23
    • 13
    • 13
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    PAPTKPHDYR QEQPETFWIQ RAPQLPTWWP LPTQVPAAED YLTWKEWGFT
    Homologie
    Cow: 79%, Dog: 93%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 93%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against SPAG8. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human SPAG8
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    Discover our top product SPAG8 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 501 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Dyrbye, Broholm, Dziegiel, Laursen: "The M129V polymorphism of codon 129 in the prion gene (PRNP) in the Danish population." in: European journal of epidemiology, Vol. 23, Issue 1, pp. 23-7, (2008) (PubMed).

  • Target
    SPAG8 (Sperm Associated Antigen 8 (SPAG8))
    Andere Bezeichnung
    SPAG8 (SPAG8 Produkte)
    Synonyme
    BS-84 antikoerper, HSD-1 antikoerper, SMP1 antikoerper, SPAG3 antikoerper, hSMP-1 antikoerper, MH-SPAG8 antikoerper, sperm associated antigen 8 antikoerper, SPAG8 antikoerper, Spag8 antikoerper
    Hintergrund
    The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. SPAG8 is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa.The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
    Alias Symbols: BS-84, HSD-1, MGC26201, SMP1, SPAG3, hSMP-1
    Protein Interaction Partner: KLHL32, DTX2, SNRPC, CSTF2, PITX1, JMJD4, WHSC1L1, KDM3B, CARM1, PRMT5, PRMT1, PRMT2, RANBP9, UBQLN4, NEDD4L, RAN,
    Protein Size: 501
    Molekulargewicht
    53 kDa
    Gen-ID
    26206
    NCBI Accession
    NM_172312, NP_758516
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