SPAG8 Antikörper (N-Term)

Produktnummer ABIN2786289

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SPAG8 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Kaninchen und Saccharomyces cerevisiae.Es wurde in 1 Publikation zitiert.

Kurzübersicht für SPAG8 Antikörper (N-Term) (ABIN2786289)

Target: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Reaktivität: Human, Kaninchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPAG8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SPAG8 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: SPAG8 Antibody - N-terminal region

Sequenz: SGPVLGSSSG AGHGSGSGSG PGCGSVPGSG SGPGPGSGPG SGPGHGSGSH

Homologie: Human: 100%, Rabbit: 86%, Yeast: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SPAG8. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SPAG8

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55621-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SPAG8 Antikörper (ABIN2786289)

Dyrbye, Broholm, Dziegiel, Laursen: "The M129V polymorphism of codon 129 in the prion gene (PRNP) in the Danish population." in: European journal of epidemiology, Vol. 23, Issue 1, pp. 23-7, (2008) (PubMed).

Details zu SPAG8

Target: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Andere Bezeichnung: SPAG8

Hintergrund:

Background Information: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. SPAG8 is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Gene Name: Sperm associated antigen 8

Alternative Symbols: SMP1, BS-84, CT142, HSD-1, SPAG3, CILD28, hSMP-1

Protein Name: Sperm-associated antigen 8

Molekulargewicht: 53kDa

Gen-ID: 26206

NCBI Accession: NP_758516

UniProt: Q99932