Sphingomyelin Synthase 1 Antikörper (Middle Region)

Produktnummer ABIN2786225

Der Kaninchen Polyklonal Anti-Sphingomyelin Synthase 1-Antikörper wurde für WB validiert. Er ist geeignet, Sphingomyelin Synthase 1 in Proben von Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Pferd und Zebrafisch (Danio rerio) zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Sphingomyelin Synthase 1 Antikörper (Middle Region) (ABIN2786225)

Target: Sphingomyelin Synthase 1 (SGMS1)

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sphingomyelin Synthase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Sphingomyelin Synthase 1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: LTTVMISVVH ERVPPKEVQP PLPDTFFDHF NRVQWAFSIC EINGMILVGL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against Sgms1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Sgms1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 419 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Sphingomyelin Synthase 1 Antikörper (ABIN2786225)

Miyamoto, Hsu, Hamm, Darshi, Diamond-Stanic, Declèves, Slater, Pennathur, Stauber, Dorrestein, Sharma: "Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator." in: EBioMedicine, Vol. 7, pp. 121-34, (2016) (PubMed).

Details zu Sphingomyelin Synthase 1

Target: Sphingomyelin Synthase 1 (SGMS1)

Andere Bezeichnung: Sgms1

Hintergrund: Bidirectional lipid cholinephosphotransferase is capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Sgms1 directly and specifically recognizes the choline head group on the substrate. It also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Sgms1 does not function strictly as a SM synthase and suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sgms1 may protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
Alias Symbols: 9530058O11Rik, AI841905, C80702, MGC30540, Mob, Sms1, Sor1, Tmem23
Protein Size: 419

Molekulargewicht: 46 kDa

Gen-ID: 208449

NCBI Accession: NM_144792, NP_659041

UniProt: Q8VCQ6

Pathways: Cellular Response to Molecule of Bacterial Origin