CARD8 Antikörper (N-Term)

Produktnummer ABIN2786065

Produktdetails anti-CARD8 Antikörper

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LGGTFPGDIC SEENQIVSSY ASKVCFEIEE DYKNRQFLGP EGNVDVELID

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CARD8. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CARD8

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CARD8

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Andere Bezeichnung: CARD8 (CARD8 Produkte)

Synonyme: CARD8 antikoerper, CARDINAL antikoerper, DACAR antikoerper, DAKAR antikoerper, NDPP antikoerper, NDPP1 antikoerper, TUCAN antikoerper, caspase recruitment domain family, member 8 antikoerper, caspase recruitment domain-containing protein 8 antikoerper, caspase recruitment domain family member 8 antikoerper, CARD8 antikoerper, LOC718594 antikoerper

Hintergrund: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
Protein Interaction Partner: ELAVL1, CARD16, CARD8, CARD18, NLRP2, NLRP3, FHL2, CASP9, IKBKG, CASP1, CARD6,
Protein Size: 286

Molekulargewicht: 31 kDa

Gen-ID: 22900

Pathways: Positive Regulation of Endopeptidase Activity