CARD8 Antikörper (N-Term)

Produktnummer ABIN2786065

Der Kaninchen Polyklonal anti-CARD8 Antikörper wird verwendet zum Nachweis von CARD8 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für CARD8 Antikörper (N-Term) (ABIN2786065)

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CARD8 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: CARD8 Antibody - N-terminal region

Sequenz: LGGTFPGDIC SEENQIVSSY ASKVCFEIEE DYKNRQFLGP EGNVDVELID

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CARD8. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CARD8

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55119-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CARD8

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Andere Bezeichnung: CARD8

Hintergrund:

Background Information: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.

Gene Name: caspase recruitment domain family, member 8

Alternative Symbols: NDPP, DACAR, DAKAR, NDPP1, TUCAN, CARDINAL

Protein Name: Caspase recruitment domain-containing protein 8

Molekulargewicht: 31kDa

Gen-ID: 22900

UniProt: Q9Y2G2

Pathways: Positive Regulation of Endopeptidase Activity