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ITGB3BP Antikörper (N-Term)

ITGB3BP Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2785998
  • Target Alle ITGB3BP Antikörper anzeigen
    ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
    Bindungsspezifität
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 22
    • 4
    • 3
    • 1
    • 1
    Human
    Wirt
    • 20
    • 2
    Kaninchen
    Klonalität
    • 20
    • 2
    Polyklonal
    Konjugat
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ITGB3BP Antikörper ist unkonjugiert
    Applikation
    • 11
    • 8
    • 7
    • 2
    Western Blotting (WB)
    Sequenz
    TGTCQMSLFA SPTSSEEQKH RNGLSNEKRK KLNHPSLTES KESTTKDNDE
    Homologie
    Human: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against ITGB3BP. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB3BP
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    Discover our top product ITGB3BP Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 177 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
    Andere Bezeichnung
    ITGB3BP (ITGB3BP Produkte)
    Synonyme
    CENP-R antikoerper, CENPR antikoerper, HSU37139 antikoerper, NRIF3 antikoerper, TAP20 antikoerper, 4930471O16Rik antikoerper, AU022583 antikoerper, integrin subunit beta 3 binding protein antikoerper, integrin beta 3 binding protein (beta3-endonexin) antikoerper, ITGB3BP antikoerper, Itgb3bp antikoerper
    Hintergrund
    ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
    Alias Symbols: CENP-R, CENPR, HSU37139, NRIF3, TAP20
    Protein Interaction Partner: PIH1D2, UBR7, ARFIP2, COL4A3BP, KIFC3, KDM1A, UBC, APP, CENPP, CENPO, SVIL, MAPK6, ACTN2, MTA1, ITGB3BP, DDX24, RECQL5, RXRA, ITGB3, NFKB1, ITGB5, ESR1, CCNA2, THRA, RELA, RXRG,
    Protein Size: 177
    Molekulargewicht
    20 kDa
    Gen-ID
    23421
    NCBI Accession
    NM_014288, NP_055103
    UniProt
    Q13352
    Pathways
    Neurotrophin Signalübertragung
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