LOXL1 Antikörper (N-Term)

Produktnummer ABIN2785878

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-LOXL1 Antikörper (ABIN2785878) detektiert spezifisch LOXL1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Kaninchen, Meerschweinchen und Pferd.

Kurzübersicht für LOXL1 Antikörper (N-Term) (ABIN2785878)

Target: LOXL1 (Lysyl Oxidase-Like 1 (LOXL1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LOXL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LOXL1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: LOXL1 Antibody - N-terminal region

Sequenz: RWRQLIQWEN NGQVYSLLNS GSEYVPAGPQ RSESSSRVLL AGAPQAQQRR

Homologie: Cow: 83%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against LOXL1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LOXL1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104714

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-LOXL1 Antikörper (ABIN2785878)

Ohmura, Yasukawa, Minami, Sugi, Oba, Nagata, Kyogoku, Ohshima, Aoki, Imaizumi: "Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice." in: Hypertension research : official journal of the Japanese Society of Hypertension, Vol. 35, Issue 11, pp. 1063-8, (2012) (PubMed).

Details zu LOXL1

Target: LOXL1 (Lysyl Oxidase-Like 1 (LOXL1))

Andere Bezeichnung: LOXL1

Hintergrund:

Background Information: LOXL1 is a member of the lysyl oxidase family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Lysyl oxidase-like 1

Alternative Symbols: LOL, LOXL

Protein Name: Lysyl oxidase homolog 1

Molekulargewicht: 63 kDa

Gen-ID: 4016

NCBI Accession: NP_005567

UniProt: Q08397