KPNA3 Antikörper (N-Term)

Produktnummer ABIN2785825

Der Kaninchen Polyklonal Anti-KPNA3-Antikörper wurde für WB validiert. Er ist geeignet, KPNA3 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen und Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für KPNA3 Antikörper (N-Term) (ABIN2785825)

Target: KPNA3 (Karyopherin alpha 3 (Importin alpha 4) (KPNA3))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KPNA3 Antikörper

Bindungsspezifität: N-Term

Sequenz: AENPSLENHR IKSFKNKGRD VETMRRHRNE VTVELRKNKR DEHLLKKRNV

Homologie: Cow: 77%, Dog: 77%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KPNA3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KPNA3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 521 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KPNA3

Target: KPNA3 (Karyopherin alpha 3 (Importin alpha 4) (KPNA3))

Andere Bezeichnung: KPNA3

Hintergrund: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion, larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3 is a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggest that karyopherin alpha-3 may be involved in the nuclear transport system.The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion, larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IPOA4, SRP1gamma, SRP4, hSRP1, SRP1
Protein Interaction Partner: TEX37, SLC5A11, APOL6, RPRD1A, ZCCHC10, MAT2B, NUP50, TSSC4, ZBTB24, DDX21, MTA1, HNRNPC, FTL, MVP, HSF1, UBC, MMS19, KPNA6, MCM6, MCM4, HDAC1, UL122, NACC1, NFE2L2, MYOD1, GTF2H1, GATA6, ERCC3, EPHA2, CBX5, TP53BP1, BARD1, ZNF131, COIL, CUL3, Ranbp2, Mki
Protein Size: 521

Molekulargewicht: 58 kDa

Gen-ID: 3839

NCBI Accession: NM_002267, NP_002258

UniProt: O00505

Pathways: Protein targeting to Nucleus