Granulin Antikörper (Middle Region)

Produktnummer ABIN2785816

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Granulin in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Pferd, Rind (Kuh), Hund und Kaninchen.

Kurzübersicht für Granulin Antikörper (Middle Region) (ABIN2785816)

Target: Granulin (GRN)

Reaktivität: Human, Pferd, Rind (Kuh), Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Granulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Granulin Antikörper

Bindungsspezifität: Middle Region

Sequenz: CPMPNATCCS DHLHCCPQDT VCDLIQSKCL SKENATTDLL TKLPAHTVGD

Homologie: Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Rabbit: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against GRN. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human GRN

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Granulin

Target: Granulin (GRN)

Andere Bezeichnung: GRN

Hintergrund: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Alias Symbols: CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Protein Interaction Partner: OTX1, HOXA1, DLX2, SGTA, KRTAP26-1, KRTAP10-7, CCDC33, ARFGAP1, FANCL, NLK, GLRX3, EED, HECW2, Hk3, RPS6KA1, NPM1, POT1, FRAT1, YY1, TGM2, RAC1, PRKAB2, PIK3R2, SMAD9, KRT18, CRY1, CFTR, CCNG1, FBXO6, GFI1B, ATN1, CDK2, CRKL, VHL, SIRT3, ATXN7, CACNA1A, C
Protein Size: 438

Molekulargewicht: 48 kDa

Gen-ID: 2896

NCBI Accession: NM_002087, NP_002078