IMPDH2 Antikörper (N-Term)

Produktnummer ABIN2785673

Produktdetails anti-IMPDH2 Antikörper

Target: IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IMPDH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against IMPDH2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human IMPDH2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 514 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu IMPDH2

Target: IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))

Andere Bezeichnung: IMPDH2 (IMPDH2 Produkte)

Synonyme: imp2 antikoerper, impd2 antikoerper, impdh-ii antikoerper, impdh2 antikoerper, IMPD2 antikoerper, IMPDH-II antikoerper, IMPD 2 antikoerper, IMPDH 2 antikoerper, cb635 antikoerper, wu:fb64g02 antikoerper, wu:fc43f09 antikoerper, IMPD antikoerper, inosine monophosphate dehydrogenase 2 antikoerper, IMP (inosine 5'-monophosphate) dehydrogenase 2 antikoerper, inosine 5'-phosphate dehydrogenase 2 antikoerper, IMPDH2 antikoerper, impdh2.S antikoerper, impdh2 antikoerper, Impdh2 antikoerper

Hintergrund: IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Alias Symbols: IMPD2, IMPDH-II
Protein Interaction Partner: RSG1, APIP, HUWE1, UBC, IMPDH2, CDK2, RPA1, RPA3, RPA2, PRKAR2A, IMPDH1, EIF2S3, PARK2, MAPK10, SOX2, NPM1, PEX14, FN1, RPLP0P6, RPS6, RPL15, FOLR1, FBXO6, GRB2, UBQLN4, PIAS4, COPS5, COPS6, CUL3, YWHAZ, FBXO25, SIRT7, HDAC5, MME, SUMO4, AKT1, IKBKE, ATG5
Protein Size: 514

Molekulargewicht: 56 kDa

Gen-ID: 3615

NCBI Accession: NM_000884, NP_000875

UniProt: P12268

Pathways: Ribonucleoside Biosynthetic Process, SARS-CoV-2 Protein Interaktom