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GCAP1 Antikörper (N-Term)

GUCA1A Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Schwein, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2785648
  • Target Alle GCAP1 (GUCA1A) Antikörper anzeigen
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Bindungsspezifität
    • 15
    • 10
    • 9
    • 5
    • 1
    • 1
    N-Term
    Reaktivität
    Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Schwein, Kaninchen
    Wirt
    • 40
    • 1
    Kaninchen
    Klonalität
    • 40
    • 1
    Polyklonal
    Konjugat
    • 13
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GCAP1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 22
    • 15
    • 13
    • 13
    • 7
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    LYEFRQFFGL KNLSPSASQY VEQMFETFDF NKDGYIDFME YVAALSLVLK
    Homologie
    Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against GUCA1A. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human GUCA1A
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    Discover our top product GUCA1A Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 201 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Andere Bezeichnung
    GUCA1A (GUCA1A Produkte)
    Synonyme
    C6orf131 antikoerper, COD3 antikoerper, CORD14 antikoerper, GCAP antikoerper, GCAP1 antikoerper, GUCA antikoerper, GUCA1 antikoerper, dJ139D8.6 antikoerper, MGC84170 antikoerper, GUCA1A antikoerper, guca1a antikoerper, MGC146317 antikoerper, GC-A antikoerper, Gcap1 antikoerper, Guca1 antikoerper, mGCAP1 antikoerper, gcap1 antikoerper, guanylate cyclase activator 1A antikoerper, guanylate cyclase activator 1A L homeolog antikoerper, guanylate cyclase activator 1A (retina) antikoerper, guanylate cyclase activator 1a (retina) antikoerper, GUCA1A antikoerper, Guca1a antikoerper, guca1a.L antikoerper, guca1a antikoerper
    Hintergrund
    GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3), a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations, causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
    Alias Symbols: COD3, GCAP, GCAP1, GUCA, GUCA1, CORD14, C6orf131, dJ139D8.6
    Protein Interaction Partner: GUCY2D,
    Protein Size: 201
    Molekulargewicht
    23 kDa
    Gen-ID
    2978
    NCBI Accession
    NM_000409, NP_000400
    UniProt
    P43080
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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