Coilin Antikörper (C-Term)

Produktnummer ABIN2785484

Produktdetails anti-Coilin Antikörper

Target: Coilin (COIL)

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Coilin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DYSLLPLLAA APQVGEKIAF KLLELTSSYS PDVSDYKEGR ILSHNPETQQ

Homologie: Cow: 93%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%, Zebrafish: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against COIL. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human COIL

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 576 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Coilin

Target: Coilin (COIL)

Andere Bezeichnung: COIL (COIL Produkte)

Hintergrund: COIL is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies.The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CLN80, p80-coilin
Protein Interaction Partner: MFAP1, FGF12, BYSL, WDR34, ZCCHC10, ARMCX1, ZNF277, PDLIM5, CDC23, SNRPF, PTS, POLR2L, PDE4D, DRG1, WWOX, UBL5, CSNK2A2, UBC, VCP, TAF9, LACTB2, KYNU, SMN2, SMN1, GTF2F1, APP, UBD, PLEKHG4, KAZN, PSME3, FAM115A, SART3, PREPL, FXR2, PICK1, FHL5, DNAJA3, KA
Protein Size: 576

Molekulargewicht: 63 kDa

Gen-ID: 8161

NCBI Accession: NM_004645, NP_004636

UniProt: P38432

Pathways: Ribonucleoprotein Complex Subunit Organization