PDE12 Antikörper (Middle Region)

Produktnummer ABIN2785355

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PDE12 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Hund und Kaninchen.

Kurzübersicht für PDE12 Antikörper (Middle Region) (ABIN2785355)

Target: PDE12 (Phosphodiesterase 12 (PDE12))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PDE12 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: PDE12 Antibody - middle region

Sequenz: CLDYIFIDLN ALEVEQVIPL PSHEEVTTHQ ALPSVSHPSD HIALVCDLKW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against 2'-PDE. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human 2'-PDE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP53350-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PDE12

Target: PDE12 (Phosphodiesterase 12 (PDE12))

Andere Bezeichnung: PDE12

Hintergrund:

Background Information: 2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Gene Name: Phosphodiesterase 12

Alternative Symbols: 2-PDE, 2'-PDE

Protein Name: 2',5'-phosphodiesterase 12

Molekulargewicht: 67kDa

Gen-ID: 201626

NCBI Accession: NP_808881

UniProt: Q6L8Q7