PDE12 Antikörper (Middle Region)

Produktnummer ABIN2785355

Produktdetails anti-PDE12 Antikörper

Target: PDE12 (Phosphodiesterase 12 (PDE12))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: CLDYIFIDLN ALEVEQVIPL PSHEEVTTHQ ALPSVSHPSD HIALVCDLKW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against 2'-PDE. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human 2'-PDE

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 609 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PDE12

Target: PDE12 (Phosphodiesterase 12 (PDE12))

Andere Bezeichnung: PDE12 (PDE12 Produkte)

Hintergrund: 2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
Alias Symbols: 2'-PDE
Protein Interaction Partner: SUMO2, SUMO1, UBC, NEDD8, DCTPP1, NPLOC4, UBQLN2, EHD1, WDR4, PDLIM5, SAE1, UBA2, CUL5, XPNPEP1, STAT6, RAD23B, PGGT1B, DNAJB1, ADSL, APEX2, COPS5, CUL3, UBL4A,
Protein Size: 609

Molekulargewicht: 67 kDa

Gen-ID: 201626

NCBI Accession: NM_177966, NP_808881

UniProt: Q6L8Q7