PACRG Antikörper (Middle Region)

Produktnummer ABIN2785168

Dieser Anti-PACRG Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von PACRG in WB. Geeignet für Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Pferd, Meerschweinchen und Kaninchen. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für PACRG Antikörper (Middle Region) (ABIN2785168)

Target: PACRG (PARK2 Co-Regulated (PACRG))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PACRG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PACRG Antikörper

Bindungsspezifität: Middle Region

Sequenz: GAIMARCNLD HLGSSDPPTS ASQVAEIIVN SGDGIDYSQQ KRENIGDLIQ

Homologie: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PACRG. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PACRG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 296 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PACRG Antikörper (ABIN2785168)

Taylor, Song, Huang, Farrer, Delatycki, Halliday, Lockhart: "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases." in: Neurobiology of disease, Vol. 27, Issue 2, pp. 238-47, (2007) (PubMed).

Verrengia Guerrero, Taylor, Simkiss: "Modelling 2,4-dichlorophenol bioavailability and bioaccumulation by the freshwater fingernail clam Sphaerium corneum using artificial particles and humic acids." in: Environmental pollution (Barking, Essex : 1987), Vol. 145, Issue 1, pp. 238-44, (2006) (PubMed).

Details zu PACRG

Target: PACRG (PARK2 Co-Regulated (PACRG))

Andere Bezeichnung: PACRG

Hintergrund: PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death.This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FLJ32724, GLUP, HAK005771, PARK2CRG, RP3-495O10.2
Protein Interaction Partner: UBC, TUBB, HOPX, CCT5, CCT8, CCT2, CCT4, CCT7, STUB1, TUBA1A, VCP, CCT3, TCP1, PARK2, HSP90AA1, HSPA4, DNAJA1, GPR37, CCT6A, APP,
Protein Size: 296

Molekulargewicht: 33 kDa

Gen-ID: 135138

NCBI Accession: NM_152410, NP_689623

UniProt: Q96M98