PACRG Antikörper (Middle Region)

Produktnummer ABIN2785168

Dieses Anti-PACRG-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PACRG in WB. Geeignet für Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Pferd, Meerschweinchen und Kaninchen. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für PACRG Antikörper (Middle Region) (ABIN2785168)

Target: PACRG (PARK2 Co-Regulated (PACRG))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PACRG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PACRG Antikörper

Bindungsspezifität: Middle Region

Sequenz: GAIMARCNLD HLGSSDPPTS ASQVAEIIVN SGDGIDYSQQ KRENIGDLIQ

Homologie: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PACRG. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PACRG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 296 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PACRG Antikörper (ABIN2785168)

Taylor, Song, Huang, Farrer, Delatycki, Halliday, Lockhart: "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases." in: Neurobiology of disease, Vol. 27, Issue 2, pp. 238-47, (2007) (PubMed).

Verrengia Guerrero, Taylor, Simkiss: "Modelling 2,4-dichlorophenol bioavailability and bioaccumulation by the freshwater fingernail clam Sphaerium corneum using artificial particles and humic acids." in: Environmental pollution (Barking, Essex : 1987), Vol. 145, Issue 1, pp. 238-44, (2006) (PubMed).

Details zu PACRG

Target: PACRG (PARK2 Co-Regulated (PACRG))

Andere Bezeichnung: PACRG

Hintergrund: PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death.This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FLJ32724, GLUP, HAK005771, PARK2CRG, RP3-495O10.2
Protein Interaction Partner: UBC, TUBB, HOPX, CCT5, CCT8, CCT2, CCT4, CCT7, STUB1, TUBA1A, VCP, CCT3, TCP1, PARK2, HSP90AA1, HSPA4, DNAJA1, GPR37, CCT6A, APP,
Protein Size: 296

Molekulargewicht: 33 kDa

Gen-ID: 135138

NCBI Accession: NM_152410, NP_689623

UniProt: Q96M98