MTPN Antikörper (Middle Region)

Produktnummer ABIN2785128

Produktdetails anti-MTPN Antikörper

Target: MTPN (Myotrophin (MTPN))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTPN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GRKPLHYAAD CGQLEILEFL LLKGADINAP DKHHITPLLS AVYEGHVSCV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against MTPN. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MTPN

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 118 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MTPN Antikörper (ABIN2785128)

Nghiem, Hoffman, Mittal, Brown, Schatzberg, Ghimbovschi, Wang, Kornegay: "Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs." in: The American journal of pathology, Vol. 183, Issue 5, pp. 1411-24, (2013) (PubMed).

Details zu MTPN

Target: MTPN (Myotrophin (MTPN))

Andere Bezeichnung: MTPN (MTPN Produkte)

Synonyme: MGC76285 antikoerper, GCDP antikoerper, V-1 antikoerper, Gcdp antikoerper, wu:fa10f07 antikoerper, zgc:64078 antikoerper, 5033418D15Rik antikoerper, V1 antikoerper, myotrophin antikoerper, myotrophin S homeolog antikoerper, mtpn antikoerper, MTPN antikoerper, Mtpn antikoerper, mtpn.S antikoerper

Hintergrund: MTPN has a potential role in cerebellar morphogenesis. MTPN may function in differentiation of cerebellar neurons, particularly of granule cells. MTPN seems to be associated with cardiac hypertrophy.The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
Alias Symbols: FLJ31098, GCDP, V-1
Protein Interaction Partner: RBBP4, RAB1A, PTPN11, OXCT1, MTAP, PDIA3, ATP6V1A, UBC, NPLOC4, ELAVL1, MAPK1, CAPZB, RELA, NFKB1, REL, DSTYK,
Protein Size: 118

Molekulargewicht: 13 kDa

Gen-ID: 136319

NCBI Accession: NM_145808, NP_665807

UniProt: P58546