CAPN10 Antikörper (N-Term)

Produktnummer ABIN2784913

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CAPN10 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Kaninchen, Meerschweinchen und Rind (Kuh).

Kurzübersicht für CAPN10 Antikörper (N-Term) (ABIN2784913)

Target: CAPN10 (Calpain 10 (CAPN10))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Meerschweinchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAPN10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CAPN10 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: CAPN10 Antibody - N-terminal region

Sequenz: MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CAPN10. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAPN10

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52404-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CAPN10

Target: CAPN10 (Calpain 10 (CAPN10))

Andere Bezeichnung: CAPN10

Hintergrund:

Background Information: CAPN10 is the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.

Gene Name: Calpain 10

Alternative Symbols: CANP10, NIDDM1

Protein Name: Calpain-10

Molekulargewicht: 58kDa

Gen-ID: 11132

NCBI Accession: NP_075573

UniProt: Q9HC96

Pathways: Positive Regulation of Peptide Hormone Secretion