METAP2 Antikörper (N-Term)

Produktnummer ABIN2784850

Dieses Anti-METAP2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von METAP2 in WB und IHC. Geeignet für Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio) und Kaninchen.

Kurzübersicht für METAP2 Antikörper (N-Term) (ABIN2784850)

Target: METAP2 (Methionyl Aminopeptidase 2 (METAP2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser METAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-METAP2 Antikörper

Bindungsspezifität: N-Term

Sequenz: ATGKKKKKKK KKRGPKVQTD PPSVPICDLY PNGVFPKGQE CEYPPTQDGR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against METAP2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human METAP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 478 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu METAP2

Target: METAP2 (Methionyl Aminopeptidase 2 (METAP2))

Andere Bezeichnung: METAP2

Hintergrund: METAP2 is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site.This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MAP2, MNPEP, p67, p67eIF2
Protein Interaction Partner: UBC, DAK, NPEPPS, GBP1, GAPDH, HMGA1, MTOR, EEF2K, APP, CALM1, S100A4, RAC1, MAPK3, EIF2S3, MAPK1, EIF2AK2, CDC42, E2F4,
Protein Size: 478

Molekulargewicht: 53 kDa

Gen-ID: 10988

NCBI Accession: NM_006838, NP_006829

UniProt: P50579

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling