POLR3C Antikörper (Middle Region)

Produktnummer ABIN2784816

Produktdetails anti-POLR3C Antikörper

Target: POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLR3C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VEAIIASMQA TGAEEAQLQE IEEMITAPER QQLETLKRNV NKLDASEIQV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against POLR3C. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human POLR3C

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 534 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu POLR3C

Target: POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

Andere Bezeichnung: POLR3C (POLR3C Produkte)

Synonyme: rpc3 antikoerper, rpc62 antikoerper, 4933407E01Rik antikoerper, RPC3 antikoerper, RPC62 antikoerper, zgc:56348 antikoerper, polymerase (RNA) III (DNA directed) polypeptide C (62kD) S homeolog antikoerper, RNA polymerase III subunit C antikoerper, polymerase (RNA) III (DNA directed) polypeptide C (62kD) antikoerper, polymerase (RNA) III (DNA directed) polypeptide C antikoerper, polr3c.S antikoerper, POLR3C antikoerper, polr3c antikoerper, Polr3c antikoerper

Hintergrund: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. POLR3C may direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. POLR3C may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.POLR3C acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3C can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Alias Symbols: RPC3, RPC62
Protein Interaction Partner: PNMA5, CEP63, ROPN1, TNR, ROCK1, TRIM27, UBC, VCP, POLR1C, POLR2E, APP, POLR3H, NOC4L, RSL1D1, POLR3A, POLR3G, POLR3F, GTF3C4, POLR3D, TBP, GTF3C3, GTF3C5, GTF3C2, GTF3C1,
Protein Size: 534

Molekulargewicht: 60 kDa

Gen-ID: 10623

NCBI Accession: NM_006468, NP_006459

UniProt: Q9BUI4