POLR3C Antikörper (Middle Region)

Produktnummer ABIN2784816

Der Kaninchen Polyklonal anti-POLR3C Antikörper wird verwendet zum Nachweis von POLR3C in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen und Saccharomyces cerevisiae. Er wurde validiert für WB.

Kurzübersicht für POLR3C Antikörper (Middle Region) (ABIN2784816)

Target: POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLR3C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-POLR3C Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: POLR3C Antibody - middle region

Sequenz: VEAIIASMQA TGAEEAQLQE IEEMITAPER QQLETLKRNV NKLDASEIQV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against POLR3C. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human POLR3C

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52190-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu POLR3C

Target: POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

Andere Bezeichnung: POLR3C

Hintergrund:

Targeted Subunit: RPC3

Background Information: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. POLR3C may direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. POLR3C may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.POLR3C acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3C can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Name: Polymerase (RNA) III (DNA directed) polypeptide C (62kD)

Alternative Symbols: C82, RPC3, RPC62

Protein Name: DNA-directed RNA polymerase III subunit RPC3

Molekulargewicht: 60kDa

Gen-ID: 10623

NCBI Accession: NP_006459

UniProt: Q9BUI4