DLC1 Antikörper (C-Term)

Produktnummer ABIN2784792

Produktdetails anti-DLC1 Antikörper

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DLC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NLAVCLAPSL FHLNTLKREN SSPRVMQRKQ SLGKPDQKDL NENLAATQGL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against DLC1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DLC1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 467 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DLC1

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Andere Bezeichnung: DLC1 (DLC1 Produkte)

Synonyme: ARHGAP7 antikoerper, HP antikoerper, STARD12 antikoerper, p122-RhoGAP antikoerper, rhogap7 antikoerper, DLC-1 antikoerper, StARD12 antikoerper, Dlc-1 antikoerper, A730069N07Rik antikoerper, Arhgap7 antikoerper, dlc-1 antikoerper, RhoGAP antikoerper, Dlc1 antikoerper, DLC1 Rho GTPase activating protein antikoerper, DLC1 Rho GTPase activating protein S homeolog antikoerper, rho GTPase-activating protein 7 antikoerper, deleted in liver cancer 1 antikoerper, DLC1 antikoerper, dlc1.S antikoerper, dlc1 antikoerper, LOC100456847 antikoerper, Dlc1 antikoerper, LOC100729904 antikoerper

Hintergrund: This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p22-p21.3, a region frequently deleted in solid tumors. It is suggested that this gene is a candidate tumor suppressor gene for human liver cancer, as well as for prostate, lung, colorectal, and breast cancers. DLC1 functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization.
Alias Symbols: ARHGAP7, FLJ21120, HP, STARD12, p122-RhoGAP
Protein Interaction Partner: DDB1, FBXW5, CUL1, CUL2, CUL3, CUL4A, UBC, TENC1, CAV1, S100A10, WWC1, AKT1,
Protein Size: 467

Molekulargewicht: 52 kDa

Gen-ID: 10395

NCBI Accession: NM_001164271

UniProt: Q9Y238

Pathways: Tube Formation, Positive Regulation of Endopeptidase Activity