CLK1 Antikörper (N-Term)

Produktnummer ABIN2784736

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-CLK1 Antikörper (ABIN2784736) detektiert spezifisch CLK1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen und Ratte.

Kurzübersicht für CLK1 Antikörper (N-Term) (ABIN2784736)

Target: CLK1 (CDC like Kinase 1 (CLK1))

Reaktivität: Human, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CLK1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: CLK1 Antibody - N-terminal region

Sequenz: HSSAQENKRC KYNHSKMCDS HYLESRSINE KDYHSRRYID EYRNDYTQGC

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against CLK1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CLK1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52021-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CLK1 Antikörper (ABIN2784736)

Aubol, Wu, Keshwani, Movassat, Fattet, Hertel, Fu, Adams: "Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing." in: Molecular cell, Vol. 63, Issue 2, pp. 218-228, (2016) (PubMed).

Eisenreich, Zakrzewicz, Huber, Thierbach, Pepke, Goldin-Lang, Schultheiss, Pries, Rauch: "Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells." in: Oncology reports, Vol. 30, Issue 1, pp. 462-70, (2013) (PubMed).

Details zu CLK1

Target: CLK1 (CDC like Kinase 1 (CLK1))

Andere Bezeichnung: CLK1

Hintergrund:

Background Information: This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: CDC-like kinase 1

Alternative Symbols: CLK, STY, CLK/STY

Protein Name: Dual specificity protein kinase CLK1

Molekulargewicht: 57kDa

Gen-ID: 1195

NCBI Accession: NP_004062

UniProt: P49759