CENPB Antikörper (C-Term)

Produktnummer ABIN2784717

Der Kaninchen Polyklonal anti-CENPB Antikörper (ABIN2784717) detektiert spezifisch CENPB in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Pferd, Schwein, Schaf, Rind (Kuh), Saccharomyces cerevisiae und Zebrafisch (Danio rerio).

Kurzübersicht für CENPB Antikörper (C-Term) (ABIN2784717)

Target: CENPB (Centromere Protein B (CENPB))

Reaktivität: Human, Maus, Ratte, Pferd, Schwein, Schaf, Rind (Kuh), Saccharomyces cerevisiae, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CENPB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CENPB Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: CENPB Antibody - C-terminal region

Sequenz: GGEDSDSDSE EEDDEEEDDE DEDDDDDEED GDEVPVPSFG EAMAYFAMVK

Homologie: Cow: 83%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 86%, Rat: 100%, Sheep: 86%, Yeast: 100%, Zebrafish: 75%

Produktmerkmale: This is a rabbit polyclonal antibody against CENPB. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CENPB

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP51969-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CENPB

Target: CENPB (Centromere Protein B (CENPB))

Andere Bezeichnung: CENPB

Hintergrund:

Background Information: CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Centromere protein B, 80 kDa

Alternative Symbols: -

Protein Name: Major centromere autoantigen B

Molekulargewicht: 65kDa

Gen-ID: 1059

NCBI Accession: NP_001801

UniProt: P07199