SENP6 Antikörper (C-Term)

Produktnummer ABIN2784244

Der Kaninchen Polyklonal anti-SENP6 Antikörper wird verwendet zum Nachweis von SENP6 in Proben von Human, Maus, Ratte, Rind (Kuh), Pferd, Schwein, Hund und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für SENP6 Antikörper (C-Term) (ABIN2784244)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Schwein, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SENP6 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Senp6 Antibody - C-terminal region

Sequenz: LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Senp6. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50599-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Andere Bezeichnung: Senp6

Hintergrund:

Background Information: Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Gene Name: SUMO/sentrin specific peptidase 6

Alternative Symbols: Susp1, mKIAA0797, 2810017C20Rik, E130319N12Rik

Protein Name: Sentrin-specific protease 6

Molekulargewicht: 127kDa

Gen-ID: 215351

NCBI Accession: NP_666115

UniProt: Q6P7W0