SIN3B Antikörper (Middle Region)

Produktnummer ABIN2784242

Produktdetails anti-SIN3B Antikörper

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIN3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NDTKALRSKS LLNEIESVYD EHQEQHSEGR SAPSSEPHLI FVYEDRQILE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SIN3B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SIN3B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1162 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SIN3B Antikörper (ABIN2784242)

Dhanda, Lindberg, Olsson: "The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues." in: BMC molecular biology, Vol. 9, pp. 8, (2008) (PubMed).

Details zu SIN3B

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Andere Bezeichnung: SIN3B (SIN3B Produkte)

Synonyme: fj63d08 antikoerper, si:dkey-6n6.6 antikoerper, wu:fj63d08 antikoerper, 2810430C10Rik antikoerper, SIN3 transcription regulator family member B antikoerper, SIN3 transcription regulator family member B S homeolog antikoerper, transcriptional regulator, SIN3B (yeast) antikoerper, sin3b antikoerper, SIN3B antikoerper, sin3b.S antikoerper, Sin3b antikoerper

Hintergrund: SIN3B acts as a transcriptional repressor. It interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities.It also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. SIN3B also forms a complex with FOXK1 which represses transcription.
Alias Symbols: KIAA0700
Protein Interaction Partner: SOX2, HDAC1, HDAC2, UBC, ESR1, AR, TFAP4, TP53, SUMO2, KLF16, MORF4L1, MORF4L2, MRGBP, KDM5A, CIITA, NR1D2, COPS2, SMN1, PBX1, REST, ZBTB4, ARID4A, MYT1, MXI1, SAP25, SMARCE1, SMARCB1, SMARCA4, SMARCA2, CBFA2T3, RNF220, ZBTB16, SETDB1, HDAC9, IKZF4, IKZF1
Protein Size: 1162

Molekulargewicht: 133 kDa

Gen-ID: 23309

NCBI Accession: NM_015260, NP_056075

UniProt: O75182