FLASH Antikörper (N-Term)

Produktnummer ABIN2784233

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FLASH in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Schwein und Kaninchen und wurde in 1 Publikation erwähnt.

Kurzübersicht für FLASH Antikörper (N-Term) (ABIN2784233)

Target: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLASH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FLASH Antikörper

Bindungsspezifität: N-Term

Sequenz: SLKKNISALI KTARVEINRK DEEISNLHQR LSEFPHFRNN HKTARTFDTV

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CASP8AP2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CASP8AP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1982 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FLASH Antikörper (ABIN2784233)

Lee, Pi, Lee: "Buffer optimization for high resolution of human lung cancer tissue proteins by two-dimensional gel electrophoresis." in: Biotechnology letters, Vol. 31, Issue 1, pp. 31-7, (2008) (PubMed).

Details zu FLASH

Target: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Andere Bezeichnung: CASP8AP2

Hintergrund: CASP8AP2 is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CED-4, FLASH, FLJ11208, KIAA1315, RIP25
Protein Interaction Partner: ced-3, BCL2L1, PML, CTBP2, CREM, SUMO1, SUMO2, PIAS1, CASP10, TRIM21, UBC, CALM1, UBE2I, SREBF2, GLUL, SP100, CASP8AP2, FADD, TRAF2, CASP8, FAS,
Protein Size: 1982

Molekulargewicht: 223 kDa

Gen-ID: 9994

NCBI Accession: NM_012115, NP_036247

UniProt: Q9UKL3

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity