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SPRY2 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-SPRY2-Antikörper wurde für WB und IHC validiert. Er ist geeignet, SPRY2 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Schwein und Meerschweinchen zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN2784217

Kurzübersicht für SPRY2 Antikörper (N-Term) (ABIN2784217)

Target

Alle SPRY2 Antikörper anzeigen
SPRY2 (Sprouty Homolog 2 (SPRY2))

Reaktivität

  • 41
  • 23
  • 14
  • 7
  • 4
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Schwein, Meerschweinchen

Wirt

  • 45
  • 3
  • 1
  • 1
Kaninchen

Klonalität

  • 46
  • 4
Polyklonal

Konjugat

  • 41
  • 3
  • 2
  • 2
  • 1
  • 1
Dieser SPRY2 Antikörper ist unkonjugiert

Applikation

  • 42
  • 23
  • 22
  • 13
  • 9
  • 7
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 7
    • 7
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequenz

    MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR

    Homologie

    Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%

    Produktmerkmale

    This is a rabbit polyclonal antibody against SPRY2. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N terminal region of human SPRY2
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 315 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Hsu, Lee, Hartstein, Harocopos: "Clostridium perfringens Keratitis Leading to Blinding Panophthalmitis." in: Cornea, Vol. 27, Issue 10, pp. 1200-3, (2008) (PubMed).

  • Target

    SPRY2 (Sprouty Homolog 2 (SPRY2))

    Andere Bezeichnung

    SPRY2

    Hintergrund

    SPRY2 is a protein belonging to the sprouty family. It contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. SPRY2 is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. SPRY2 may play a role in alveoli branching during lung development as shown by a similar mouse protein.This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MGC23039, hSPRY2
    Protein Interaction Partner: PTGER3, PRKAB2, KRTAP4-11, ATRIP, KRTAP5-6, KRTAP10-3, KRTAP10-8, KRTAP10-5, KRTAP10-11, KRTAP10-1, KRTAP10-9, LCE3E, KRTAP5-9, GP9, OTX1, MLLT6, MEOX2, MDFI, LASP1, LCE2D, LCE1B, RUNX1T1, AQP1, LCE3C, LCE4A, ZNF417, HEXIM2, CATSPER1, LONRF1, KRTAP4-7, KR
    Protein Size: 315

    Molekulargewicht

    35 kDa

    Gen-ID

    10253

    NCBI Accession

    NM_005842, NP_005833

    UniProt

    O43597

    Pathways

    EGFR Signaling Pathway, Sensory Perception of Sound, EGFR Downregulation
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