PCDHA6 Antikörper (C-Term)

Produktnummer ABIN503116

Produktdetails anti-PCDHA6 Antikörper

Target: PCDHA6 (Protocadherin alpha 6 (PCDHA6))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Pferd, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCDHA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LVKDHGEPAL TATATVLVSL VESGQAPKAS SRASVGAAGP EAALVDVNVY

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PCDHA6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHA6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 803 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PCDHA6

Target: PCDHA6 (Protocadherin alpha 6 (PCDHA6))

Andere Bezeichnung: PCDHA6 (PCDHA6 Produkte)

Hintergrund: PCDHA6 contains 6 cadherin domains. It is a potential calcium-dependent cell-adhesion protein. PCDHA6 may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Alias Symbols: CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6
Protein Interaction Partner: CUL3, UBC, RELN,
Protein Size: 803

Molekulargewicht: 84 kDa

Gen-ID: 56142

NCBI Accession: NM_031848, NP_114036