PCDHA6 Antikörper (C-Term)

Produktnummer ABIN2784011

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PCDHA6 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Meerschweinchen, Pferd, Rind (Kuh) und Hund.

Kurzübersicht für PCDHA6 Antikörper (C-Term) (ABIN2784011)

Target: PCDHA6 (Protocadherin alpha 6 (PCDHA6))

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Pferd, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCDHA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PCDHA6 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PCDHA6 Antibody - C-terminal region

Sequenz: LVKDHGEPAL TATATVLVSL VESGQAPKAS SRASVGAAGP EAALVDVNVY

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PCDHA6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHA6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50008-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PCDHA6

Target: PCDHA6 (Protocadherin alpha 6 (PCDHA6))

Andere Bezeichnung: PCDHA6

Hintergrund:

Background Information: PCDHA6 contains 6 cadherin domains. It is a potential calcium-dependent cell-adhesion protein. PCDHA6 may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Gene Name: Protocadherin alpha 6

Alternative Symbols: CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6

Protein Name: Protocadherin alpha-6

Molekulargewicht: 84kDa

Gen-ID: 56142

NCBI Accession: NP_114036

UniProt: Q9UN73