Protocadherin alpha 6 (PCDHA6) (C-Term) Antikörper

Details zu Produkt Nr. ABIN2784011, Anbieter: Anmelden zum Anzeigen
Antigen
  • CNR2
  • CNRN2
  • CNRS2
  • CRNR2
  • PCDH-ALPHA6
  • CNR
  • Cnr2
  • Crnr2
  • rCNRv06
  • PCDHA3
  • PCDHA6
  • PCDHA7
  • PCDHA9
  • protocadherin alpha 6
  • PCDHA6
  • Pcdha6
Epitop
C-Term
9
8
7
5
3
3
2
2
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Ratte (Rattus)
62
26
25
2
2
1
1
1
1
1
Wirt
Kaninchen
54
9
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
46
28
20
14
13
5
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHA6
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN981453.
Sequenz LVKDHGEPAL TATATVLVSL VESGQAPKAS SRASVGAAGP EAALVDVNVY
Homologie Cow: 86%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against PCDHA6. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung PCDHA6 (PCDHA6 Antibody Abstract)
Hintergrund PCDHA6 contains 6 cadherin domains. It is a potential calcium-dependent cell-adhesion protein. PCDHA6 may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Alias Symbols: CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6
Protein Interaction Partner: CUL3, UBC, RELN,
Protein Size: 803
Molekulargewicht 84 kDa
Gen-ID 56142
NCBI Accession NM_031848, NP_114036
Applikations-hinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 803 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Protocadherin alpha 6 (PCDHA6) (C-Term) antibody (ABIN2784011) WB Suggested Anti-PCDHA6 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Pos...
Allgemeine Veröffentlichungen Schmutz, Martin, Terry, Couronne, Grimwood, Lowry, Gordon, Scott, Xie, Huang, Hellsten, Tran-Gyamfi, She, Prabhakar, Aerts, Altherr, Bajorek, Black, Branscomb, Caoile, Challacombe, Chan, Denys et al.: "The DNA sequence and comparative analysis of human chromosome 5. ..." in: Nature, Vol. 431, Issue 7006, pp. 268-74, 2004 (PubMed).

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