PCDHGC4 Antikörper (Protocadherin gamma Subfamily C, 4) (N-Term)

Details for Product anti-PCDHGC4 Antibody No. ABIN2783728, Anbieter: Anmelden zum Anzeigen
Antigen
  • PCDH-GAMMA-C4
  • protocadherin gamma c4
  • protocadherin gamma subfamily C, 4
  • Pcdhgc4
  • PCDHGC4
Epitop
N-Term
14
10
8
2
2
1
1
1
Reaktivität
Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus), Zebrafisch (Danio rerio)
44
19
17
1
1
1
1
Wirt
Kaninchen
43
1
Klonalität
Polyklonal
Konjugat
Dieser PCDHGC4 Antikörper ist unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
27
19
13
6
4
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PCDHGC4
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN981463.
Sequenz VKKRSDGSLV PELLLEKPLD REKQSDYRLV LTAVDGGNPP RSGTAELRVS
Homologie Horse: 100%, Human: 100%, Mouse: 100%, Pig: 91%, Rabbit: 79%, Rat: 100%, Zebrafish: 100%
Produktmerkmale This is a rabbit polyclonal antibody against PCDHGC4. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung PCDHGC4 (PCDHGC4 Antibody Abstract)
Hintergrund PCDHGC4 is a single-pass type I membrane protein. It contains 6 cadherin domains.PCDHGC4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Alias Symbols: MGC119489, PCDH-GAMMA-C4
Protein Size: 938
Molekulargewicht 98 kDa
Gen-ID 56098
NCBI Accession NM_018928, NP_061751
UniProt Q9Y5F7
Forschungsgebiet Signaling
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 938 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Protocadherin gamma Subfamily C, 4 (PCDHGC4) (N-Term) antibody (ABIN2783728) WB Suggested Anti-PCDHGC4 Antibody Titration: 0.2-1 ug/ml
Positive Contr...
Allgemeine Veröffentlichungen Wu, Zhang, Cheng, Kim, Grimwood, Schmutz, Dickson, Noonan, Zhang, Myers, Maniatis: "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." in: Genome research, Vol. 11, Issue 3, pp. 389-404, 2001 (PubMed).

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