NEK3 Antikörper (N-Term)

Produktnummer ABIN2783629

Produktdetails anti-NEK3 Antikörper

Target: NEK3 (NIMA related kinase 3 (NEK3))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FTQMCLGVNH IHKKRVLHRD IKSKNIFLTQ NGKVKLGDFG SARLLSNPMA

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Yeast: 79%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against NEK3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NEK3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 506 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NEK3

Target: NEK3 (NIMA related kinase 3 (NEK3))

Andere Bezeichnung: NEK3 (NEK3 Produkte)

Hintergrund: NEK3 is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. It differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase.In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized.
Alias Symbols: HSPK36, MGC29949
Protein Interaction Partner: HDAC6, NMNAT1, CDCA8, BPGM, VAV2, PRLR, VAV1, CSN2,
Protein Size: 506

Molekulargewicht: 58 kDa

Gen-ID: 4752

NCBI Accession: NM_002498, NP_002489

UniProt: P51956