CHST14 Antikörper (Middle Region)

Produktnummer ABIN2783597

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-CHST14 Antikörper wird verwendet zum Nachweis von CHST14 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Schwein und Meerschweinchen. Er wurde validiert für WB.

Kurzübersicht für CHST14 Antikörper (Middle Region) (ABIN2783597)

Target: CHST14 (Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 14 (CHST14))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHST14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CHST14 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: CHST14 Antibody - middle region

Sequenz: REYQQRYGAE IVRRYRAGAG PSPAGDDVTF PEFLRYLVDE DPERMNEHWM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CHST14. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CHST14

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48994-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CHST14 Antikörper (ABIN2783597)

Janecke, Li, Boehm, Krabichler, Rohrbach, Müller, Fuchs, Golas, Katagiri, Ziegler, Gahl, Wilnai, Zoppi, Geller, Giunta, Slavotinek, Steinmann: "The phenotype of the musculocontractural type of Ehlers-Danlos syndrome due to CHST14 mutations." in: American journal of medical genetics. Part A, Vol. 170A, Issue 1, pp. 103-15, (2016) (PubMed).

Details zu CHST14

Target: CHST14 (Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 14 (CHST14))

Andere Bezeichnung: CHST14

Hintergrund:

Background Information: CHST14 belongs to the sulfotransferase 2 family. CHST14 catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. It transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. It transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. CHST14 has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA.

Gene Name: Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14

Alternative Symbols: ATCS, D4ST1, EDSMC1, HNK1ST

Protein Name: Carbohydrate sulfotransferase 14

Molekulargewicht: 35kDa

Gen-ID: 113189

UniProt: Q8NCH0

Pathways: Glycosaminoglycan Metabolic Process