ALG2 Antikörper (C-Term)

Produktnummer ABIN2783587

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-ALG2 Antikörper (ABIN2783587) detektiert spezifisch ALG2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae, Ziege und Zebrafisch (Danio rerio).

Kurzübersicht für ALG2 Antikörper (C-Term) (ABIN2783587)

Target: ALG2 (Asparagine-Linked Glycosylation 2, alpha-1,3-Mannosyltransferase Homolog (ALG2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae, Ziege, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ALG2 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: ALG2 Antibody - C-terminal region

Sequenz: QSDLGQYVTF LRSFSDKQKI SLLHSCTCVL YTPSNEHFGI VPLEAMYMQC

Homologie: Cow: 100%, Dog: 93%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against ALG2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ALG2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48974-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ALG2 Antikörper (ABIN2783587)

Cossins, Belaya, Hicks, Salih, Finlayson, Carboni, Liu, Maxwell, Zoltowska, Farsani, Laval, Seidhamed, Donnelly, Bentley, McGowan, Müller, Palace, Lochmüller, Beeson: "Congenital myasthenic syndromes due to mutations in ALG2 and ALG14." in: Brain : a journal of neurology, Vol. 136, Issue Pt 3, pp. 944-56, (2013) (PubMed).

Rind, Schmeiser, Thiel, Absmanner, Lübbehusen, Hocks, Apeshiotis, Wilichowski, Lehle, Körner: "A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip." in: Human molecular genetics, Vol. 19, Issue 8, pp. 1413-24, (2010) (PubMed).

Details zu ALG2

Target: ALG2 (Asparagine-Linked Glycosylation 2, alpha-1,3-Mannosyltransferase Homolog (ALG2))

Andere Bezeichnung: ALG2

Hintergrund:

Background Information: ALG2 is a member of the glycosyltransferase 1 family. It acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii).This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)

Alternative Symbols: CDG1I, CDGIi, CMS14, NET38, CMSTA3, hALPG2

Protein Name: Alpha-1,3/1,6-mannosyltransferase ALG2

Molekulargewicht: 47kDa

Gen-ID: 85365

NCBI Accession: NP_149078

UniProt: Q9H553